InCandida albicans, resistance to flucytosine and terbinafine is linked toMAT locus homozygosity and multilocus sequence typing clade 1
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چکیده
منابع مشابه
Enrichment of multilocus sequence typing clade 1 with oral Candida albicans isolates in patients with untreated periodontitis.
This study investigated the prevalence and cell density of Candida species in periodontal pockets, healthy subgingival sites, and oral rinse samples of patients with untreated periodontitis. Twenty-one periodontitis patients underwent sampling at two periodontitis sites, and 19/21 of these patients underwent sampling at one periodontally healthy site. Both paper point and curette sampling techn...
متن کاملPopulation structure and properties of Candida albicans, as determined by multilocus sequence typing.
We submitted a panel of 416 isolates of Candida albicans from separate sources to multilocus sequence typing (MLST). The data generated determined a population structure in which four major clades of closely related isolates were delineated, together with eight minor clades comprising five or more isolates. By Fisher's exact test, a statistically significant association was found between partic...
متن کاملCollaborative consensus for optimized multilocus sequence typing of Candida albicans.
A panel of 86 different Candida albicans isolates was subjected to multilocus sequence typing (MLST) in two laboratories to obtain sequence data for 10 published housekeeping gene fragments. Analysis of data for all possible combinations of five, six, seven, eight, and nine of the fragments showed that a set comprising the fragments AAT1a, ACC1, ADP1, MPIb, SYA1, VPS13, and ZWF1b was the smalle...
متن کاملMultilocus sequence typing reveals evidence of homologous recombination linked to antibiotic resistance in the genus Salinispora.
The three closely related species that currently comprise the genus Salinispora were analyzed using a multilocus sequence typing approach targeting 48 strains derived from four geographic locations. Phylogenetic congruence and a well-supported concatenated tree provide strong support for the delineation of the three species as currently described and the basal relationship of Salinispora arenic...
متن کاملClade-specific flucytosine resistance is due to a single nucleotide change in the FUR1 gene of Candida albicans.
Population studies have indicated that natural resistance to flucytosine (5FC) in Candida albicans is limited to one of the five major clades, clade I. In addition, while 73% of clade I isolates are less susceptible to 5FC (MIC >/= 0.5 microg/ml), only 2% of non-clade I isolates are less susceptible. In order to determine the genetic basis for this clade-specific resistance, we sequenced two ge...
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ژورنال
عنوان ژورنال: FEMS Yeast Research
سال: 2009
ISSN: 1567-1356,1567-1364
DOI: 10.1111/j.1567-1364.2009.00577.x